Olfactory Receptor Neuron Dysfunction in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Dysregulation of olfactory receptor neuron lineage in schizophrenia.
BACKGROUND Growing evidence implicates abnormal neurodevelopment in schizophrenia. While neuron birth and differentiation is largely completed by the end of gestation, the olfactory epithelium (OE) is a unique part of the central nervous system that undergoes regeneration throughout life, thus offering an opportunity to investigate cellular and molecular events of neurogenesis and development p...
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Compound action potentials were recorded from rat olfactory receptor neuron axons at measured distances from the stimulation electrode along the lateral surface of the main olfactory bulb. Distances were plotted as a function of the latencies measured from stimulus onset to the prominent negative trough of the triphasic compound action potential. A straight line was fitted to these data to calc...
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Most natural odors are mixtures and often elicit percepts distinct from those elicited by their constituents. This emergence of a unique odor quality has long been attributed to central processing. Here we show that sophisticated integration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila. Odor mixtures are encoded in the temporal dynamics as well as in the ma...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2008
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2008.139